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HELLO Every one and Greetings to all. I am Heymaavathi Kreeshnaan, a student of Institute of nanoelectronics engineering, University Malaysia Perrlis, Under the supervision of Associate Prof Dr. Subash Chandra Bose Gopinath. In conjunction with e-reka 2021, I would like to present our poster entitled on Archimedean nano MIP Sensor; a prognostic device for clotting disease detection. Blood clotting is a natural phenomenon when an injury occurs on our body. A series of protein undergoes this clotting cascade to clot the blood and to stop the excessive bleeding. Imbalance of these proteins and excessive procoagulants causes hypercoagulation which leads to chronic diseases such as heart failure and organ damages, stroke, deep vein thrombosis and pulmonary embolism. It was reported that, 23.1% of fatality rate of Malaysia last year was from stroke and heart failure. Hypercoagulation increases risk when one undergoes surgery. Clotting assay is a preliminary procedure for a surgical patient to determine the blood clotting level. Based on these assay, anticoagulant medications will be injected on the patient before surgery to keep the patient’s blood uncoagulated along the operation. Platelet count, bleeding time, activated partial thromboplastin time and prothrombin time are the common assays. However, these assays are laborious, costly and time consuming. So, what we need is, a rapid, sensitive point of care monitoring sensor for high performance detection of clotting diathesis. When it comes to biosensor, one must have a superior receptors and effective transducer. Conventional receptors such as antibodies, DNA and RNAs are low stable, costly and sensitive to pH and high temperature. This is where we get the idea of the project. The fist idea is enhancing sensing material by artificial receptors which is molecularly imprinted polymer, also called MIP. The second idea is the transducer material and design, where we used Archimedean spiral pattern. What is MIP? Lets assume is our target protein and X and Y are macro and micro monomers. The first step is pre-polymerization. In this step, functional monomers are pre-assemble with protein by forming non-covalent interactions. Next step is radical or electro polymerization method to give a rigid, porous structure surrounding the pre-assembled complex. Finally, when protein is removed from the polymer, it leaves a cavity with the memory of target protein. This is a simple simulation how a target protein perfectly fits into MIP polymer. We started the project with an in silico analysis to explore the interactions between, aptamer-protein and aptamer-protein towards functional monomers. This video shows a trajectory of our molecular dynamics simulation. Based on those data, MIP was synthesized by radical polymerization. In this case, 2-fluro RNA aptamer was used as macromonomer and methacrylic was used a micro monomers. Archimedean Sensor fabrication was conducted by conventional photolithography technique. Aluminium was used as conducting element. These of SEM, high performance microscopy, 3d and AFM images of fabricated sensor. Synthesized MIP nanoparticles were immobilized on fabricated Archimedean sensor. The figures show the sensor morphology before and after MIP deposition. We have developed a novel biosensor for high performance analysis by conjugating carbon nano horn and gold nano urchin as hybrid materials. They elevates the performance of the sensor and gives large surface area to avoid crowded effect of MIP nanoparticles. These are the FESEM images of carbon nano horn and gold nano urchin. This is a cartoon image of our developed prototype. And the photographs of the prototype is shown form different perspectives.