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Laboratory test results are usually normal in patients with OA, although they may be useful for narrowing the differential diagnoses when the diagnosis is uncertain. C-reactive protein levels and erythrocyte sedimentation rate can be useful to evaluate for systemic inflammatory conditions and autoimmune disorders. A uric acid level may help evaluate for the presence of gout. Clinical guidelines established by the American College of Rheumatology recommend against routine ordering of arthritis panels for patients with joint problems.