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Age is one of the strongest predictors of OA, with incidence of hand, hip, and knee OA increasing with age, especially after the age of 50 years . A leveling-off occurs at all joint sites around the age of 80 years. Approximately 14 percent of adults aged 25 and older have symptomatic OA of at least one joint, while 34 percent of adults aged 65 and older have OA . Worldwide estimates are that 10 percent of men and 18 percent of women aged over 60 years have symptomatic OA. The mechanisms behind this increased risk with increasing age are not well known. Possible causes are sarcopenia, loss of proprioception, and joint laxity that may affect joint function and predispose the joint to injury. Changes affecting joint tissues include loss of normal bone structure, increased stiffness of ligaments and tendons, and meniscal degeneration