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In 1952, a semester before Ernesto "Fuser" Guevara is due to complete his medical degree, he and his older friend Alberto, a biochemist, leave Buenos Aires in order to travel across the South American continent in search of fun and adventures. While there is a goal at the end of their journey - they intend to work in a leper colony in Peru - the main purpose is tourism. They want to see as much of Latin America as they can, more than 8,000 kilometres (5000 miles). Their initial method of transport is Alberto's ancient and leaky but functional Norton 500 motorcycle christened La Poderosa ("The Mighty One"). Their route is ambitious. They head south, aim to cross the Andes, travel along the coast of Chile, across the Atacama Desert and into the Peruvian Amazon and reach Venezuela just in time for Alberto's 30th birthday, April 2. Due to La Poderosa's breakdown, they are forced to travel at a much slower pace and make it to Caracas in July.