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The effects of substance abuse on human life expectancy are well-known and often discussed. However, it is crucial to remember that other stressors and insults can also cause premature aging in the body. Any of these factors can lead to a loss of reserve capacity and, ultimately, a shortened lifespan, from environmental pollutants to trauma to systemic infections. It is essential to consider the cumulative impact of these various stressors, as they can significantly impact our longevity. Taking steps to limit exposure to harmful substances and protect our bodies from physical and biological insults can add years to our lives. And while we may not have control over every aspect that contributes to aging, being aware of the potential effects can help us make informed choices for self-care and longevity.