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This article entitled “MicroRNA Expression of Primary and Metastatic Colorectal and Breast Carcinoma”, published in Ramathibodi Medical Journal, Volume 45 Number 3. Colorectal and breast carcinoma are frequently diagnosed cancers. At advanced stages, cancers metastasize to certain organs resulting in loss of function of these organs, and eventually death. Therefore, there is a specific need for the prognosis of these cancers. Currently, microRNAs have emerged as a new target of cancer-specific biomarker. This study aimed to examine the expression of microRNA in primary and metastatic breast and colorectal cancers. The expressions of 6 microRNAs were investigated; including miR-10b, miR-21, miR-145, miR-155, miR-200c, and miR-373, in formalin fixed paraffin embed tissues from pairs of normal tissues with primary and metastatic tumor samples of breast and colorectal carcinoma cases in Ramathibodi Hospital, by real-time RT-PCR. The results showed that, miR-145 decreased significantly in all samples of primary and metastatic colorectal and breast carcinoma. There was significantly decreased expression of miR-145 in metastatic colorectal carcinoma compared to their primary colorectal carcinoma. Whereas miR-10b, miR-155, and miR-200c showed a decreased expression; miR-21 and miR-373 showed an increased expression in the majority of cases. Unlike miR-145, other miRNAs showed no significant difference of expression. This finding indicates that miR-145 may be the potential metastatic biomarker. Decrease of miR-145 could be applied to the prognosis and target for therapy of breast and colorectal carcinoma. For more information of this article, please visit the official website of Ramathibodi Medical Journal.