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Cardinals solve scoring woes with help of 22-point burst in under two minutes to beat Saints GLENDALE, Ariz. -- The Arizona Cardinals' defense changed the game with pick-sixes of quarterback Andy Dalton on back-to-back drives just before halftime, and the team continued to pour it on in the second half to beat the New Orleans Saints 42-34. The Cardinals' 42 points are their most in a game since Week 17 of 2016 and the most under coach Kliff Kingsbury. The win breaks a streak of eight straight home losses for Arizona, which had been tied for the team's longest home losing streak since 1940. The Cardinals needed this win in the worst possible way. They were off to a 2-4 start, their offense was anemic and they were on the brink of an early-season tailspin. And then they put together this performance on national TV behind an impressive defensive showing, highlighted by two interceptions returned for touchdowns. The two pick-sixes -- one by cornerback Marco Wilson followed by one by linebacker Isaiah Simmons on consecutive drives -- put the Cardinals in command of a game that was tied at 14 before the first pick-six. Thursday night could be defining game of the Cardinals' season. DeAndre Hopkins made an impact in his first game back from suspension. He had 103 yards on 10 catches, reacclimating to the offense as well as the Cardinals could have hoped. But the defense finding its rhythm against the pass, while complementing an offense that found its own rhythm, was what the Cardinals needed to potentially turn the season around.