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Hello, everyone, I am Longgang Zhao. I will present our recent study on behalf of all my coauthors on associations between sugar-sweetened beverage intake, liver cancer and chronic liver disease mortality using the Women’s Health Initiative study. I have no conflicts to disclose. Both the incidence and mortality of liver cancer is increasing in the last three decades in US population. Liver cancer ranked 13th in cancer incidence and 6th in cancer-related mortality in 2019. Chronic liver diseases have been increasing since last two decades. It has been the 4th leading cause for middle aged women and 5th leading cause for middle aged men. Some risk factors of liver cancer and liver disease have been well investigated. However, there are still more than 30% of liver cancers that could not be explained by all these known risk factors. The recent report from the World Cancer Research Fund continuous update project in 2018, only alcohol and coffee have been classified as strong evidence to be associated with liver cancer. Studies on whether and how other dietary factors are associated with liver cancer or liver diseases are still under investigation. Sugar-sweetened beverage, a well-established risk factor for obesity and cardiovascular diseases, has raised health concerns. Even though the consumption of soft drink decreased in recent years in US, but other types of SSB like fruit drinks are increasing. Only one European cohort and one US study reported positive associations between soft drinks and the risk of liver cancer. But none of them reported separate results for women due to sample size. Therefore, we aimed to investigate the association between total SSB and artificially sweetened beverages, and the risk of liver cancer and CLD mortality in the US postmenopausal women using the Women’s Health Initiative. We included participants from the WHI observational study and the comparison arm of the diet modification clinical trials. After exclusion, we included around 0.1 million participants in the current analyses. At baseline, we collected the SSB intake by asking the participants about the frequency of soft drink and fruit drink intake during the last 3 months. We further categorized the participants into three groups based on the beverage intake. The liver cancer was self-reported and further confirmed by a medical record review. CLD mortality was defined based on ICD-10 codes from the National Death Index. We used Cox proportional hazards regression model to estimate the hazard ratio for associations of SSB or ASB intake with adverse liver outcomes. We included participants from the WHI observational study and the comparison arm of the diet modification clinical trials. After exclusion, we included around 0.1 million participants in the current analyses. At baseline, we collected the SSB intake by asking the participants about the frequency of soft drink and fruit drink intake during the last 3 months. We further categorized the participants into three groups based on the beverage intake. The liver cancer was self-reported and further confirmed by a medical record review. CLD mortality was defined based on ICD-10 codes from the National Death Index. We used Cox proportional hazards regression model to estimate the hazard ratio for associations of SSB or ASB intake with adverse liver outcomes. We included the following risk factors as potential confounders in our multiple variable adjusted model. After a median of 20.9 years of follow-up, 207 women had confirmed liver cancer and 148 died due to CLD. Women who consumed more SSB were more likely to be younger, with higher BMI, less physically active, and higher energy intake. After controlling for potential confounders, we found that compared with the lowest intake group, women who consumed more than or equal to 1 serving of SSB daily has about 85% higher risk of liver cancer. The results were similar for soft drinks and fruit drinks. We found a non-significant positive association between ASB and liver cancer. Similarly, we observed higher intake of SSB was associated with higher risk of CLD mortality. The association between ASB and CLD mortality is null. Our results were stable in several sensitivity analyses. In general, we found higher SSB intake is a potential risk factor for liver cancer and CLD mortality in postmenopausal women. We also found null association between ASB intake and liver health. Studies in men and diverse populations are needed to examine these associations and elucidate the potential biological mechanisms.