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It is not possible to remove pimples overnight. Treatments for pimples and acne take time to work. Individual pimples may take a few days or a few weeks to completely heal. The amount of time it takes for a blemish to go away can depend on how large or severe it is, and how a person treats it. For example, picking or popping the pimple may increase healing times. Careful treatment at home can reduce swelling and pain.