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AROA ECM is an advanced regenerative technology made from isolated tissue from the forestomach of pasture-raised New Zealand sheep. The forestomach has evolved to maximize nutrient absorption, meaning it has developed extensive vasculature, and also demonstrates constant tissue turnover to enable it to cope with processing of harsh food types. This remarkable combination of advanced structure and biology makes it an ideal tissue source for soft tissue repair technologies. Using AROAs proprietary mild method of decellularization, the forestomach tissue is gently processed to remove only unwanted components, leaving behind the intact extracellular matrix or ECM. The AROA ECM technology has a similar structure and biology to human tissue ECM making it a universal platform for soft tissue regeneration. In normal healthy tissue, the ECM is a critical platform for continuous dynamic and reciprocal communication and signaling between cells. Additionally, the ECM provides a physical scaffold to support cells. Both these functions are key for ongoing tissue maintenance, and especially important during soft tissue repair. In acute or chronic soft tissue defects, the ECM is missing, or damaged and wound healing may be compromised, especially in patients with diseases such as diabetes, vascular disease, or obesity. The AROA ECM contains the necessary naturally occurring ECM components responsible for providing signals, structure, and cell adhesion, becoming a platform for soft tissue repair. The AROA ECM can be used to replace missing or damaged ECM, to augment the patient’s own healing. The Aroa ECM retains the native organized structure of healthy tissue ECM to provide a robust porous bioscaffold comprised of collagens, laminin, elastins and other structural proteins. This supports the infiltration of the patients’ own cells, including fibroblasts, inflammatory cells, and endothelial cells. This facilitates the building of new healthy tissue. AROA ECM contains residual vascular channels. In a process called ‘angioconduction’, endothelial cells utilize these channels as a template to help build new blood vessels and rapidly vascularize the newly forming tissue. When processing the forestomach tissue, the epithelial and endothelial basement membranes (comprising collagen IV, laminin and perlecan) are retained. The basement membranes serve a critical role in the adhesion of patients’ cells to the AROA ECM during cell repopulation and tissue growth. The AROA ECM contains over 150 natural ECM proteins found in normal healthy tissue such as: Protease inhibitors that help modulate wound inflammatory proteins, thus helping overcome stalled wounds to progress to the healing phase. Growth factors to signal and mediate cell communication during tissue repair and remodeling. Published preclinical data has also demonstrated the ability of components found within AROA ECM to attract stem cells. Over time, the AROA ECM is incorporated into the soft tissue defect and is replaced by the patient’s own organized functional tissue. The AROA ECM can be used as a building block for soft tissue reconstruction across, and within the body.