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Currently, millions of people worldwide have been affected by bond or joint degenerative and inflammatory problems. Since 2008 to 2020, the population over 50 years of age with a bond disease has doubled. Then, the use of joint implants has been necessary for them. Several materials used were developed over the decades by the biomedical industry with high biocompatibility. This characteristic gives a better lifestyle to the patient despite their disease. However, prosthetic infection could be unavoidable despite the sterile environment of surgical procedures, and it affects the long lifespan of implants. The infection of an implant results in challenging problems requiring secondary surgical procedures and implant replacement . The toxic response and the subsequent infection could lead to a necrosis of the surrounding tissue ending in amputation or even mortality. Normally, the average cost in a single prosthesis treatment is $6,000 whereas the total cost for a patient with an infected prosthesis is estimated to be $30,000 and more due to the hospitalization time, antibiotic treatments, reimplantation, blood transfusion, examinations, and so on.