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Good afternoon, thank you all for coming. Today I am going to present my current experiment with the title: “Potential antifungal activity of flavones in combination therapies”, this is part of a collaboration between our group and a research group from the University of Graz. The presentation consists of the following parts. Introduction, Objectives, Methodology used, Results, Conclusion and References. Invasive fungal infections are an increasing problem worldwide, contributing to 1.6 million deaths annually and are an important cause of human mortality and morbidity, particularly for immunocompromised populations. Currently, there are only 4 types of antifungals used in clinic, and many fungal species are resistant to these drugs or are partially effective. Due to this, it is urgent to develop new strategies to combat fungal infections, and there are several strategies such as use of combination therapies, discovering new drugs OR natural compounds with possible antifungal activity alone or in synergistic combinations to overcome the problem with resistance. The use of natural compound like phenolic compounds is an excellent approach to reduce the side effects and toxicity. Phenolic compounds are bioactive phytochemicals that include multiple subclasses, one of these most studied groups of these compounds is flavonoids. These compounds are widely distributed in plants, such as fruits, vegetables, herbs, spices, and certain beverages (like tea, coffee, and wine). The flavonoids can be sub-divided in different groups. Among them, flavones and flavonols define the largest subgroups. The subgroup that interests us in this experiment are flavones, which have been reported different biological activities as antioxidant, anti-inflammatory, antimicrobial, antiviral activities, among others. In addition to these biological activities, flavones have shown antifungal activity against yeasts and filamentous fungi in different studies, how it shown in next slide, where different studies demonstrate antifungal activity of flavonoids in general or specifically flavone. Furthermore, Gratz's group also observed that some flavones such as F42 have activity against C. glabrata and C. albicans